Professor at Université Pierre et Marie Curie Deputy Director of Laboratoire des Biomolécules
My research activities are focused on the molecular basis of the interactions involving biomolecules and the design of synthetic molecules able to modulate these interactions. NMR spectroscopy is the main technique of investigation and is used in concert with molecular modelling (protein structure calculation, conformational analysis of small molecules), biochemistry (recombinant protein expression and purification), biophysical and other spectroscopic methods (circular dichroism, fluorescence). The main research axes deal with:
- Conformational studies of bioactive peptides and peptidomimetics
- Interactions of peptides and proteins with membranes
- Protein/ligand interactions
- Structural characterization of synthetic and bioorganic molecules
My teaching activities at Université Pierre et Marie Curie involve NMR spectroscopy for chemists and biochemists, as well as biological chemistry and spectroscopy courses, at the Bachelor (Licence L2, L3) and Master levels (M1, M2). I am responsible of teaching units LC351, LC361, and 3C021.
Biomolecular NMR, biochemistry, biophysics,
peptides, peptidomimetics, cell-penetrating peptide, antimicrobial peptide, amyloid peptide, homeoprotein, Engrailed transcription factor
French: mother tongue, English
Other: German, Latin, Hieroglyphic Egyptian
Olivier Lequin did his undergraduate studies at the Ecole Normale Supérieure de Lyon and Université Claude Bernard in Biochemistry and Chemistry. He received the Agrégation de Biochimie in 1992 and a Master’s degree in 1994. He continued with a PhD in 1997 under the supervision of Prof. Jean-Yves Lallemand (Ecole Polytechnique, Palaiseau, France) working on the NMR structure determination of angiogenins, ribonucleases involved in angiogenesis. In 1998, he got a FEBS postdoctoral fellowship to join Prof. Iain D. Campbell’s group (Department of Biochemistry, University of Oxford, UK), where he worked on the NMR characterization of type III modules of fibronectin involved in matrix assembly and in heparin binding. He was appointed Maître de Conférences in 1999 at Université Pierre et Marie Curie where he worked in collaboration with Gérard Chassaing and Solange Lavielle on structure-activity relationships of peptides and peptidomimetics. Since 2006 he is Professor at Université Pierre et Marie Curie in bioorganic NMR spectroscopy. He is currently Deputy Director of the laboratoire des Biomolécules (UMR 7203 UPMC-ENS-CNRS).